Sarawut Kumphune Selected Research

SB 203580

4/2021	p38 MAPK Inhibitor (SB203580) and Metformin Reduces Aortic Protein Carbonyl and Inflammation in Non-obese Type 2 Diabetic Rats.
9/2019	Combination of metformin and p38 MAPK inhibitor, SB203580, reduced myocardial ischemia/reperfusion injury in non-obese type 2 diabetic Goto-Kakizaki rats.
1/2015	Inhibition of p38 MAPK activation protects cardiac mitochondria from ischemia/reperfusion injury.
2/2013	Inhibition of p38 MAPK during ischemia, but not reperfusion, effectively attenuates fatal arrhythmia in ischemia/reperfusion heart.
1/2010	A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580.
5/2008	The role of RIP2 in p38 MAPK activation in the stressed heart.

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Sarawut Kumphune Research Topics

Disease

8	Infarction (Infarctions) 04/2022 - 01/2010
8	Ischemia 01/2021 - 05/2008
7	Reperfusion Injury 04/2021 - 01/2015
7	Myocardial Ischemia (Ischemic Heart Diseases) 04/2021 - 01/2010
3	Inflammation (Inflammations) 04/2021 - 04/2021
3	Myocardial Infarction 10/2011 - 05/2008
2	Weight Gain 01/2022 - 04/2021
2	Ventricular Fibrillation 12/2014 - 02/2013
1	Dyslipidemias (Dyslipidemia) 01/2022
1	Hypercholesterolemia 04/2021
1	Type 2 Diabetes Mellitus (MODY) 04/2021
1	Arthritis (Polyarthritis) 01/2021
1	Neoplasms (Cancer) 01/2021
1	Adenocarcinoma of Lung 01/2021
1	Heart Failure 06/2020
1	Diabetes Mellitus 06/2020
1	Hypertension (High Blood Pressure) 06/2020
1	Diabetic Cardiomyopathies 09/2019
1	Cardiomyopathies (Cardiomyopathy) 09/2019
1	Death (Near-Death Experience) 09/2019
1	B-Cell Lymphoma (Lymphoma, B Cell) 12/2017
1	Mitochondrial Diseases (Mitochondrial Disease) 12/2014
1	Cardiac Arrhythmias (Arrythmia) 02/2013
1	Ventricular Tachycardia 02/2013
1	Ventricular Dysfunction 02/2013
1	Insulin Resistance 01/2013

Drug/Important Bio-Agent (IBA)

8	p38 Mitogen-Activated Protein KinasesIBA 04/2021 - 05/2008
7	Proteins (Proteins, Gene)FDA Link 04/2022 - 05/2008
6	SB 203580IBA 04/2021 - 05/2008
5	Secretory Leukocyte Peptidase InhibitorIBA 04/2021 - 12/2017
3	AntioxidantsIBA 01/2022 - 06/2020
3	Peptide Hydrolases (Proteases)FDA Link 04/2021 - 05/2018
3	CytokinesIBA 04/2021 - 01/2021
3	EnzymesIBA 04/2021 - 05/2018
3	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2021 - 12/2014
3	Phosphotransferases (Kinase)IBA 05/2012 - 05/2008
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 04/2022 - 04/2021
2	MB Form Creatine KinaseIBA 04/2022 - 04/2021
2	Metformin (Glucophage)FDA LinkGeneric 04/2021 - 09/2019
2	Pharmaceutical PreparationsIBA 09/2019 - 01/2010
2	Cytochromes c (Cytochrome c)IBA 12/2014 - 02/2013
2	Connexin 43 (Connexin43)IBA 12/2014 - 02/2013
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2013 - 01/2010
1	Biomarkers (Surrogate Marker)IBA 04/2022
1	Acetic Acid (Vinegar)FDA LinkGeneric 01/2022
1	Triglycerides (Triacylglycerol)IBA 01/2022
1	Blood Glucose (Blood Sugar)IBA 01/2022
1	Interleukin-6 (Interleukin 6)IBA 04/2021
1	cytidylyl-(3'-5')-cytidine (CpC)IBA 04/2021
1	LipidsIBA 04/2021
1	Malondialdehyde (Propanedial)IBA 04/2021
1	CholesterolIBA 04/2021
1	IronIBA 01/2021
1	LigandsIBA 01/2021
1	ChloridesIBA 01/2021
1	Therapeutic UsesIBA 01/2021
1	SaltsIBA 01/2021
1	Schiff Bases (Schiff Base)IBA 01/2021
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 12/2017
1	triphenyltetrazoliumIBA 02/2017
1	SolutionsIBA 02/2017
1	Atropine FDA LinkGeneric 12/2014
1	Interleukin-4 (Interleukin 4)IBA 12/2014
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2014
1	salicylhydroxamic acid (SHAM)IBA 12/2014
1	Mitogen-Activated Protein KinasesIBA 02/2013
1	HSP27 Heat-Shock ProteinsIBA 02/2013
1	Insulin (Novolin)FDA Link 01/2013
1	Insulin ReceptorIBA 01/2013
1	Glucose (Dextrose)FDA LinkGeneric 01/2013
1	ischemia-modified albuminIBA 10/2011
1	EpitopesIBA 01/2010
1	Protein Isoforms (Isoforms)IBA 01/2010
1	Tyrosine (L-Tyrosine)FDA Link 01/2010
1	Threonine (L-Threonine)FDA Link 01/2010
1	Phospho-Specific AntibodiesIBA 01/2010
1	doramapimodIBA 01/2010
1	Adenosine Triphosphate (ATP)IBA 05/2008

Therapy/Procedure

1	Vagus Nerve Stimulation 12/2014